112646-88-5
112646-88-5
Chemical Structure
U-26384
- CAS No.: 112646-88-5
- Formula:C25H42N2O
- Molecular Weight:386.61
IUPAC Name: N1-((8R,9S,13S,14S,17S)-3-methoxy-13-methyl-4,6,7,8,9,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-N1,N3,N3-trimethylpropane-1,3-diamine
InChIKey: FPNKVECDQYFDBG-VAFBSOEGSA-N
SMILES: C[C@@]12[C@](CC[C@@H]2N(C)CCCN(C)C)([H])[C@@]3([H])[C@@](CC1)([H])C4=C(CC(OC)=CC4)CC3
Biological Activity: U-26384 is a Phospholipase A2 inhibitor. U-26384 reduces Sodium iodoacetate (HY-D0849)-induced Arachidonic acid (HY-109590) release and cell damage. U-26384 can be used for research on Graves' disease and ischemic brain injury[1][2].
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U-26384 | U-26384 is a Phospholipase A2 inhibitor. U-26384 reduces Sodium iodoacetate (HY-D0849)-induced Arachidonic acid (HY-109590) release and cell damage. U-26384 can be used for research on Graves' disease and ischemic brain injury. | |||||||||||||||||||||
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References
- [1]. Atwa MA, et al. Immunoglobulins from Graves' disease patients stimulate phospholipase A2 and C systems in FRTL-5 and human thyroid cells. European journal of endocrinology. 1996 Sep;135(3):322-7.
- [2]. Sun FF, et al. Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion. Biochemical pharmacology. 1993 Mar 09;45(5):1149-55.
