112791-61-4
Chemical Structure
D-myo-Inositol 3,4,5,6-tetrakisphosphate
Synonym(s): Ins(3,4,5,6)P4
- CAS No.: 112791-61-4
- Formula:C6H16O18P4
- Molecular Weight:500.07
IUPAC Name: (1S,2R,3R,4S,5R,6S)-5,6-dihydroxycyclohexane-1,2,3,4-tetrayl tetrakis(dihydrogen phosphate)
InChIKey: MRVYFOANPDTYBY-UZAAGFTCSA-N
SMILES: O(P(=O)(O)O)[C@H]1[C@H](OP(=O)(O)O)[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](O)[C@@H]1OP(=O)(O)O
Biological Activity: D-myo-Inositol 3,4,5,6-tetrakis phosphate (Ins (3,4,5,6) P4) is a InsP5/InsP4 phosphohydrolase substrate and Ins (1,3,4) P3 5/6-kinase inhibitor that can be dephosphorylated to inositol trisphosphate or converted to pentakisphosphate in an ATP-dependent manner. D-myo-Inositol 3,4,5,6-tetrakis phosphate inhibits calcium-dependent chloride secretion and CaMKII-activated chloride currents through a phosphatase-dependent mechanism, and can serve as a research tool for studying long-acting intestinal chloride flux restriction and desensitization mechanisms related to phospholipase C-related responses[1][2][3][4].
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D-myo-Inositol 3,4,5,6-tetrakisphosphate | D-myo-Inositol 3,4,5,6-tetrakis phosphate (Ins (3,4,5,6) P4) is a InsP5/InsP4 phosphohydrolase substrate and Ins (1,3,4) P3 5/6-kinase inhibitor that can be dephosphorylated to inositol trisphosphate or converted to pentakisphosphate in an ATP-dependent manner. D-myo-Inositol 3,4,5,6-tetrakis phosphate inhibits calcium-dependent chloride secretion and CaMKII-activated chloride currents through a phosphatase-dependent mechanism, and can serve as a research tool for studying long-acting intestinal chloride flux restriction and desensitization mechanisms related to phospholipase C-related responses. | |||||||||||||||||||||
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References
- [1]. Adelt S, et al. Enzyme-assisted total synthesis of the optical antipodes D-myo-inositol 3,4,5-trisphosphate and D-myo-inositol 1,5, 6-trisphosphate: aspects of their structure-activity relationship to biologically active inositol phosphates. Journal of medicinal chemistry. 1999 Apr 08;42(7):1262-73.
- [2]. Stephens LR, et al. Product-precursor relationships amongst inositol polyphosphates. Incorporation of [32P]Pi into myo-inositol 1,3,4,6-tetrakisphosphate, myo-inositol 1,3,4,5-tetrakisphosphate, myo-inositol 3,4,5,6-tetrakisphosphate and myo-inositol 1,3,4,5,6-pentakisphosphate in intact avian erythrocytes. Biochem J. 1990 Jan 15;265(2):435-52.
- [3]. Vajanaphanich M, et al. Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4. Nature. 1994 Oct 20;371(6499):711-4.
- [4]. Xie W, et al. Regulation of Ca2+-dependent Cl- conductance in a human colonic epithelial cell line (T84): cross-talk between Ins(3,4,5,6)P4 and protein phosphatases. J Physiol. 1998 Aug 1;510 ( Pt 3)(Pt 3):661-73. [Content Brief]
