112887-62-4
Chemical Structure
ICI 198583
- CAS No.: 112887-62-4
- Formula:C25H24N4O6
- Molecular Weight:476.48
IUPAC Name: (4-(((2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)(prop-2-yn-1-yl)amino)benzoyl)-L-glutamic acid
InChIKey: PMTUUSDTAKQWQJ-NRFANRHFSA-N
SMILES: O=C(CC[C@H](NC(C1=CC=C(C=C1)N(CC#C)CC2=CC3=C(C=C2)NC(C)=NC3=O)=O)C(O)=O)O
Biological Activity: ICI 198583 is a thymidylate synthase (TS) inhibitor with a Ki value of 10 nM for both mouse and human TS. ICI 198583 serves as a substrate for folylpolyglutamate synthetase (FPGS) with a Km of 40 μM. ICI 198583 exerts persistent, dose-dependent inhibition on thymidylate synthase flux in mice. ICI 198583 is applicable to relevant research on leukemia[1].
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ICI 198583 | ICI 198583 is a thymidylate synthase (TS) inhibitor with a Ki value of 10 nM for both mouse and human TS. ICI 198583 serves as a substrate for folylpolyglutamate synthetase (FPGS) with a Km of 40 μM. ICI 198583 exerts persistent, dose-dependent inhibition on thymidylate synthase flux in mice. ICI 198583 is applicable to relevant research on leukemia. | |||||||||||||||||||||
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