113277-37-5
113277-37-5
Chemical Structure
Suc-Ala-Ala-Pro-Val-AMC
- CAS No.: 113277-37-5
- Formula:C30H39N5O9
- Molecular Weight:613.66
IUPAC Name: (Z)-2-(1-fluoro-2-iodovinyl)-5-(trifluoromethyl)pyridine
InChIKey: NNGFVQWESFKLFH-BTGSAOCRSA-N
SMILES: CC(C1=CC=C(NC([C@H](C(C)C)NC([C@H]2N(CCC2)C([C@H](C)NC([C@H](C)NC(CCC(O)=O)=O)=O)=O)=O)=O)C=C1O3)=CC3=O
Biological Activity: Suc-Ala-Ala-Pro-Val-AMC is a fluorescent substrate for elastase. Suc-Ala-Ala-Pro-Val-AMC can be hydrolyzed by these elastases to release the fluorescent substance 7-amino-4-methylcoumarin. Suc-Ala-Ala-Pro-Val-AMC is used for in vitro elastase activity assays and can also be applied in studies related to chronic wounds[1][2][3].
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Suc-Ala-Ala-Pro-Val-AMC | 99.08% | Suc-Ala-Ala-Pro-Val-AMC is a fluorescent substrate for elastase. Suc-Ala-Ala-Pro-Val-AMC can be hydrolyzed by these elastases to release the fluorescent substance 7-amino-4-methylcoumarin. Suc-Ala-Ala-Pro-Val-AMC is used for in vitro elastase activity assays and can also be applied in studies related to chronic wounds. | ||||||||||||||||||||
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References
- [1]. Castillo MJ, et al. Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. Anal Biochem. 1979 Oct 15;99(1):53-64.
- [2]. Fontenot KR, et al. Designing cellulosic and nanocellulosic sensors for interface with a protease sequestrant wound-dressing prototype: Implications of material selection for dressing and protease sensor design. J Biomater Appl. 2017;32(5):622-637. [Content Brief]
- [3]. Polacek D, et al. In vitro proteolysis of human plasma low density lipoproteins by an elastase released from human blood polymorphonuclear cells. J Biol Chem. 1986;261(5):2057-2063. [Content Brief]
