1135681-23-0
Chemical Structure
VU0357017
Synonym(s): CID-25010775 free base
- CAS No.: 1135681-23-0
- Formula:C18H27N3O3
- Molecular Weight:333.43
IUPAC Name: ethyl 4-((2-(2-methylbenzamido)ethyl)amino)piperidine-1-carboxylate
InChIKey: ZBSSIYGXZQZYDM-UHFFFAOYSA-N
SMILES: O=C(N1CCC(NCCNC(C2=CC=CC=C2C)=O)CC1)OCC
Biological Activity: VU0357017 (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 can be used for the research of Alzheimer’s disease and schizophrenia[1][2][3].
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VU0357017 | VU0357017 (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 can be used for the research of Alzheimer’s disease and schizophrenia. | |||||||||||||||||||||
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References
- [1]. Digby GJ, et al. Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36. [Content Brief]
- [2]. Lebois EP, et al. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. ACS Chem Neurosci. 2010;1(2):104-121. [Content Brief]
- [3]. Digby GJ, et al. Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. J Neurosci. 2012 Jun 20;32(25):8532-44. [Content Brief]
