1135688-47-9
1135688-47-9
Chemical Structure
Z-AEVD-FMK
- CAS No.: 1135688-47-9
- Formula:C28H39FN4O10
- Molecular Weight:610.63
IUPAC Name: methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-11-isopropyl-8-(3-methoxy-3-oxopropyl)-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
InChIKey: CHZRBQFKZDGMTP-CDSYHYPYSA-N
SMILES: O=C(OC)C[C@@H](C(CF)=O)NC([C@H](C(C)C)NC([C@H](CCC(OC)=O)NC([C@H](C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O
Biological Activity: Z-AEVD-FMK is a caspase-10 inhibitor. Z-AEVD-FMK can inhibit the activation of Bid and the release of apoptosis-inducing factor (AIF) in mitochondria in cells, resulting in a significant decrease in the number of apoptotic cells[1][2].
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Z-AEVD-FMK | 95.0% | Z-AEVD-FMK is a caspase-10 inhibitor. Z-AEVD-FMK can inhibit the activation of Bid and the release of apoptosis-inducing factor (AIF) in mitochondria in cells, resulting in a significant decrease in the number of apoptotic cells. | ||||||||||||||||||||
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References
- [1]. Park SJ, et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3;279(49):51057-67. [Content Brief]
- [2]. Ekchariyawat P, et al. Apoptosis induced by avian H5N1 virus in human monocyte-derived macrophages involves TRAIL-inducing caspase-10 activation. Innate Immun. 2012 Jun;18(3):390-7. [Content Brief]
