1137264-00-6
1137264-00-6
Chemical Structure
cis-Ned19
- CAS No.: 1137264-00-6
- Formula:C30H31FN4O3
- Molecular Weight:514.59
IUPAC Name: (1S,3S)-1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
InChIKey: FUHCEERDBRGPQZ-LSYYVWMOSA-N
SMILES: O=C([C@@H]1CC2=C([C@H](C3=CC=C(OC)C(CN4CCN(C5=CC=CC=C5F)CC4)=C3)N1)NC6=C2C=CC=C6)O
Biological Activity: cis-Ned19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. cis-Ned19 localizes to lysosomes and endolysosomal vesicles, stains two-pore calcium channels and fluorescently labels NAADP receptors (Ex/Em = 365/410 nm)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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cis-Ned19 | 99.25% | cis-Ned19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. cis-Ned19 localizes to lysosomes and endolysosomal vesicles, stains two-pore calcium channels and fluorescently labels NAADP receptors (Ex/Em = 365/410 nm). | ||||||||||||||||||||
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References
- [1]. Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016;(4):430-438. [Content Brief]
- [2]. Avdonin PV, et al. Involvement of two-pore channels in hydrogen peroxide-induced increase in the level of calcium ions in the cytoplasm of human umbilical vein endothelial cells. Dokl Biochem Biophys. 2017;474(1):209-212. [Content Brief]
- [3]. Naylor E, et al. Identification of a chemical probe for NAADP by virtual screening. Nat Chem Biol. 2009 Apr;5(4):220-6. [Content Brief]
