113963-41-0
113963-41-0
Chemical Structure
Andrographidine E
- CAS No.: 113963-41-0
- Formula:C24H26O11
- Molecular Weight:490.46
InChIKey: KJWPVIVMWLREST-UKMCQSRUSA-N
SMILES: COC1=C2C(C(C=C(C3=C(C=CC=C3)OC)O2)=O)=C(C=C1OC)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO
Biological Activity: Andrographidine E is a COX-2 (IC50 = 19 μM) and HDAC inhibitor, with high affinity for HDAC1 and HDAC3. Andrographidine E can specifically bind to macrophages and has potential immunotargeting properties. Andrographidine E can be used for studying inflammation[1][2][3].
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Andrographidine E | Andrographidine E is a COX-2 (IC50 = 19 μM) and HDAC inhibitor, with high affinity for HDAC1 and HDAC3. Andrographidine E can specifically bind to macrophages and has potential immunotargeting properties. Andrographidine E can be used for studying inflammation. | |||||||||||||||||||||
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References
- [1]. Das D, et al. Exploring the potential of Andrographis paniculata for developing novel HDAC inhibitors: an in silico approach. J Biomol Struct Dyn. 2025 Jan;43(1):359-371. [Content Brief]
- [2]. Wang Y, et al. Screening and Identification for Immunological Active Components from Andrographis Herba Using Macrophage Biospecific Extraction Coupled with UPLC/Q-TOF-MS. Molecules. 2018 Apr 30;23(5):1047. [Content Brief]
- [3]. Jiao J, et al. Screening cyclooxygenase-2 inhibitors from Andrographis paniculata to treat inflammation based on bio-affinity ultrafiltration coupled with UPLC-Q-TOF-MS. Fitoterapia. 2019 Sep;137:104259. [Content Brief]
