1139889-93-2
1139889-93-2
Chemical Structure
Golgicide A
Synonym(s): GCA
- CAS No.: 1139889-93-2
- Formula:C17H14F2N2
- Molecular Weight:284.30
IUPAC Name: (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
InChIKey: NJZHEQOUHLZCOX-FTLRAWMYSA-N
SMILES: FC1=CC2=C(NC(C3=CC=CN=C3)[C@@]4([H])[C@]2([H])C=CC4)C(F)=C1
Biological Activity: Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1[1]. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Golgicide A | 99.94% | Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species. | ||||||||||||||||||||
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References
- [1]. Sáenz JB, et al. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nat Chem Biol. 2009 Mar;5(3):157-65. [Content Brief]
- [2]. van der Linden L, et al. Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. J Virol. 2010 Aug;84(15):7535-42. [Content Brief]
