114012-12-3
114012-12-3
Chemical Structure
Phaclofen
- CAS No.: 114012-12-3
- Formula:C9H13ClNO3P
- Molecular Weight:249.63
IUPAC Name: (3-amino-2-(4-chlorophenyl)propyl)phosphonic acid
InChIKey: VSGNGLJPOGUDON-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C(CN)CP(O)(O)=O)C=C1
Biological Activity: Phaclofen is a selective GABAB receptor antagonist. Phaclofen is a peripheral and central baclofen antagonist. Phaclofen maybe a potential compound in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-)-baclofen interact[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phaclofen | 99.91% | Phaclofen is a selective GABAB receptor antagonist. Phaclofen is a peripheral and central baclofen antagonist. Phaclofen maybe a potential compound in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-)-baclofen interact. | ||||||||||||||||||||
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References
- [1]. Johnson CM, et al. The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release. Neuropharmacology. 2020;176:108214. [Content Brief]
- [2]. Kerr DI, et al. Phaclofen: a peripheral and central baclofen antagonist. Brain Res. 1987;405(1):150-154. [Content Brief]
