114127-24-1
114127-24-1
Chemical Structure
erythro-Austrobailignan-6
- CAS No.: 114127-24-1
- Formula:C20H24O4
- Molecular Weight:328.40
IUPAC Name: 4-((2R,3S)-4-(benzo[d][1,3]dioxol-5-yl)-2,3-dimethylbutyl)-2-methoxyphenol
InChIKey: QDDILOVMGWUNGD-KGLIPLIRSA-N
SMILES: COC(C=C1C[C@@H](C)[C@@H](C)CC2=CC=C(OCO3)C3=C2)=C(C=C1)O
Biological Activity: erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK[1][2].
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erythro-Austrobailignan-6 | erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK. | |||||||||||||||||||||
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References
- [1]. Han JH, et al. Erythro-austrobailignan-6 down-regulates HER2/EGFR/integrinβ3 expression via p38 activation in breast cancer. Phytomedicine. 2017 Jan 15;24:24-30. [Content Brief]
- [2]. Lee YK, et al. Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis. Arch Pharm Res. 2009 Oct;32(10):1409-15. [Content Brief]
