1143863-69-7
Chemical Structure
KBU2046
- CAS No.: 1143863-69-7
- Formula:C15H11FO2
- Molecular Weight:242.25
IUPAC Name: 3-(4-fluorophenyl)chroman-4-one
InChIKey: XKAFGKFIJBGYAP-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C(F)C=C2)COC3=CC=CC=C13
Biological Activity: KBU2046 is an orally active transforming growth factor-β (TGF-β1) inhibitor. KBU2046 reduces integrin family protein expression, decreases Raf, RIPK1 and ERK phosphorylation to deactivate the ERK signaling pathway, and down-regulates genes linked to TGF-β1 maturation. KBU2046 suppresses tumor cell motility, impedes cancer invasion and metastasis, and inhibits human ESCC growth and metastasis in a murine model. KBU2046 can be used for the researches of triple-negative breast cancer and esophageal squamous cell carcinoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KBU2046 | 98.85% | KBU2046 is an orally active transforming growth factor-β (TGF-β1) inhibitor. KBU2046 reduces integrin family protein expression, decreases Raf, RIPK1 and ERK phosphorylation to deactivate the ERK signaling pathway, and down-regulates genes linked to TGF-β1 maturation. KBU2046 suppresses tumor cell motility, impedes cancer invasion and metastasis, and inhibits human ESCC growth and metastasis in a murine model. KBU2046 can be used for the researches of triple-negative breast cancer and esophageal squamous cell carcinoma. | ||||||||||||||||||||
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References
- [1]. Chen J, et al. Unveiling the therapeutic potential: KBU2046 halts triple-negative breast cancer cell migration by constricting TGF-β1 activation in vitro. Oncol Res. 2024;32(11):1791-1802. Published 2024 Oct 16. [Content Brief]
- [2]. Li K, et al. KBU2046 exerts inhibition on chemokine gradient-mediated motility of esophageal squamous cell carcinoma through reducing integrin expression. Biochim Biophys Acta Mol Basis Dis. 2025;1871(5):167800. [Content Brief]
