114417-20-8
Chemical Structure
Alilusem potassium
Synonym(s): M 17055
- CAS No.: 114417-20-8
- Formula:C17H14ClKN2O5S
- Molecular Weight:432.92
IUPAC Name: potassium (E)-(7-chloro-1-(2-methylbenzoyl)-2,3-dihydroquinolin-4(1H)-ylidene)amino sulfate
InChIKey: NQFKOWCYLQFLSM-QTCZRQAZSA-M
SMILES: O=C(C1=CC=CC=C1C)N2CC/C(C3=C2C=C(C=C3)Cl)=N\OS(=O)(O[K])=O
Biological Activity: Alilusem potassium is a diuretic. In anesthetized dogs undergoing water diuresis, Alilusem potassium effectively decreased free water clearance and increased Na+ and Cl- levels in excreted urine. When combined with Furosemide (HY-B0135) or Hydrochlorothiazid, Alilusem potassium further inhibited free water clearance. Alilusem potassium inhibited the lumen-positive transepithelial voltage and lumen-to-cistern Cl- flux in isolated rabbit cortical thick ascending limbs of Henle[1].
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Alilusem potassium | Alilusem potassium is a diuretic. In anesthetized dogs undergoing water diuresis, Alilusem potassium effectively decreased free water clearance and increased Na+ and Cl- levels in excreted urine. When combined with Furosemide (HY-B0135) or Hydrochlorothiazid, Alilusem potassium further inhibited free water clearance. Alilusem potassium inhibited the lumen-positive transepithelial voltage and lumen-to-cistern Cl- flux in isolated rabbit cortical thick ascending limbs of Henle. | |||||||||||||||||||||
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