114419-77-1
Chemical Structure
RSD-921
Synonym(s): PD-123497
- CAS No.: 114419-77-1
- Formula:C21H28N2OS
- Molecular Weight:356.52
IUPAC Name: 2-(benzo[b]thiophen-4-yl)-N-methyl-N-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)acetamide
InChIKey: SYHJZCCNQDFHJQ-RTBURBONSA-N
SMILES: O=C(N(C)[C@H]1[C@H](N2CCCC2)CCCC1)CC3=C(C=CS4)C4=CC=C3
Biological Activity: RSD-921 (PD-123497) is a potent Na+ channel blocker with anti-arrhythmic activity. RSD-921 displays a low affinity for κ-opioid receptors and behaves as a weak κ-agonist in vitro. RSD 921 displays state-, time- and voltage-dependent block of the open state of cardiac, skeletal muscle and neuronal Na+ channels expressed in Xenopus oocytes. RSD-921 can be used for cardiac arrhythmias research[1][2].
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RSD-921 | RSD-921 (PD-123497) is a potent Na+ channel blocker with anti-arrhythmic activity. RSD-921 displays a low affinity for κ-opioid receptors and behaves as a weak κ-agonist in vitro. RSD 921 displays state-, time- and voltage-dependent block of the open state of cardiac, skeletal muscle and neuronal Na+ channels expressed in Xenopus oocytes. RSD-921 can be used for cardiac arrhythmias research. | |||||||||||||||||||||
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References
- [1]. Meecham KG, et al. An in vitro profile of activity for the (+) and (-) enantiomers of spiradoline and PD117302. Eur J Pharmacol. 1989 Dec 7;173(2-3):151-7. [Content Brief]
- [2]. Pugsley MK, et al. Molecular analysis of the Na+ channel blocking actions of the novel class I anti-arrhythmic agent RSD 921. Br J Pharmacol. 1999 May;127(1):9-18. [Content Brief]
