114528-79-9
Chemical Structure
(-)-U-50488 hydrochloride
Synonym(s): (-)-Trans-(1S,2S)-U-50488 hydrochloride
- CAS No.: 114528-79-9
- Formula:C19H27Cl3N2O
- Molecular Weight:405.79
IUPAC Name: 2-(3,4-dichlorophenyl)-N-methyl-N-((1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl)acetamide hydrochloride
InChIKey: KGMMGVIYOHGOKQ-APTPAJQOSA-N
SMILES: O=C(N(C)[C@@H]1[C@@H](N2CCCC2)CCCC1)CC3=CC=C(Cl)C(Cl)=C3.[H]Cl
Biological Activity: (-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (Kd=2.2 nM) over μ-opioid receptor (MOR) (Kd=430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+) trans-(1R,2R) U-50488 (HY-15997A) or the (±) trans-racemic mixture U-50488 (HY-15997B). (-)-U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(-)-U-50488 hydrochloride | 98.95% | (-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (Kd=2.2 nM) over μ-opioid receptor (MOR) (Kd=430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+) trans-(1R,2R) U-50488 (HY-15997A) or the (±) trans-racemic mixture U-50488 (HY-15997B). (-)-U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM). | ||||||||||||||||||||
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