1145878-98-3
1145878-98-3
Chemical Structure
Galacto-PUGNAc
- CAS No.: 1145878-98-3
- Formula:C15H19N3O7
- Molecular Weight:353.33
IUPAC Name: N-((3R,4R,5R,6R,Z)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((phenylcarbamoyl)oxy)imino)tetrahydro-2H-pyran-3-yl)acetamide
InChIKey: PBLNJFVQMUMOJY-UYZOWNTJSA-N
SMILES: O[C@@H]([C@@H](CO)O/1)[C@H](O)[C@@H](NC(C)=O)C1=N\OC(NC2=CC=CC=C2)=O
Biological Activity: Galacto-PUGNAc is a selective competitive inhibitor of lysosomal β-hexosaminidases (HEX), with Ki values of 51 and 18 nM, for hHEXA and hHEXB, respectively. Galacto-PUGNAc elevates GM2 ganglioside levels in neuroblastoma cells. Galacto-PUGNAc can be used for the research of neurodegenerative disorders[1].
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Galacto-PUGNAc | Galacto-PUGNAc is a selective competitive inhibitor of lysosomal β-hexosaminidases (HEX), with Ki values of 51 and 18 nM, for hHEXA and hHEXB, respectively. Galacto-PUGNAc elevates GM2 ganglioside levels in neuroblastoma cells. Galacto-PUGNAc can be used for the research of neurodegenerative disorders. | |||||||||||||||||||||
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