1148013-87-9
Chemical Structure
11-Deoxyglycyrrhetinic acid sodium
- CAS No.: 1148013-87-9
- Formula:C30H47NaO3
- Molecular Weight:478.68
IUPAC Name: sodium (2S,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate
InChIKey: UDJPLVCFJFTZAA-QAJWEOSXSA-M
SMILES: C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](C)(CC4)C(O[Na])=O)C)C)([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC1)C
Biological Activity: 11-Deoxyglycyrrhetinic acid sodium is a compound that exhibits anti-inflammatory activity. 11-Deoxyglycyrrhetinic acid sodium activates the Ca2+/voltage-gated K+ large conductance (BK) (cbv1 + β1) channels cloned from rat cerebral artery myocytes with the EC50 of 53 μM[1][2].
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11-Deoxyglycyrrhetinic acid sodium | 11-Deoxyglycyrrhetinic acid sodium is a compound that exhibits anti-inflammatory activity. 11-Deoxyglycyrrhetinic acid sodium activates the Ca2+/voltage-gated K+ large conductance (BK) (cbv1 + β1) channels cloned from rat cerebral artery myocytes with the EC50 of 53 μM. | |||||||||||||||||||||
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References
- [1]. Siviy SM, et al. Noradrenergic modulation of play in Sprague-Dawley and F344 rats. Psychopharmacology (Berl). 2023 Jul 10. [Content Brief]
- [2]. Bukiya AN, et al. Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent. Mol Pharmacol. 2013;83(5):1030-1044. [Content Brief]
