1148125-93-2
1148125-93-2
Chemical Structure
DHODH-IN-4
- CAS No.: 1148125-93-2
- Formula:C17H12Cl2N2O2
- Molecular Weight:347.20
IUPAC Name: (Z)-2-cyano-N-(2',3-dichloro-[1,1'-biphenyl]-4-yl)-3-hydroxybut-2-enamide
InChIKey: KEZXIYKJTYTGOO-RAXLEYEMSA-N
SMILES: C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2Cl)C=C1Cl)=O
Biological Activity: DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity[1].
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DHODH-IN-4 | DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity. | |||||||||||||||||||||
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