1149753-56-9
1149753-56-9
Chemical Structure
ITK antagonist
- CAS No.: 1149753-56-9
- Formula:C26H34N6O2S
- Molecular Weight:494.65
IUPAC Name: (S)-N-(5-(((3,3-dimethylbutan-2-yl)amino)methyl)-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d]imidazol-2-yl)-5-(1H-pyrazol-4-yl)thiophene-2-carboxamide
InChIKey: MUAICZWSFWUFNA-INIZCTEOSA-N
SMILES: CC(C)(O)CN1C2=CC=C(CN[C@@H](C)C(C)(C)C)C=C2N=C1NC(C3=CC=C(C4=CNN=C4)S3)=O
Biological Activity: ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1].
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ITK antagonist | ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM. | |||||||||||||||||||||
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