115362-28-2
115362-28-2
Chemical Structure
rel-(-)-Vesamicol
Synonym(s): rel-(-)-AH5183
- CAS No.: 115362-28-2
- Formula:C17H25NO
- Molecular Weight:259.39
InChIKey: YSSBJODGIYRAMI-IAGOWNOFSA-N
SMILES: O[C@H]1[C@H](N2CCC(C3=CC=CC=C3)CC2)CCCC1
Biological Activity: rel-(-)-Vesamicol (rel-(-)-AH5183) is the racemate of (-)-Vesamicol. (-)-Vesamicol is a vesicular acetylcholine transporter inhibitor. (-)-Vesamicol reversibly and non-competitively inhibits the transport of acetylcholine into circulating synaptic vesicles and blocks the activity of vesicular acetylcholine transporters in medial amygdala neurons. (-)-Vesamicol is applicable to research related to central precocious puberty[1][2].
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rel-(-)-Vesamicol | rel-(-)-Vesamicol (rel-(-)-AH5183) is the racemate of (-)-Vesamicol. (-)-Vesamicol is a vesicular acetylcholine transporter inhibitor. (-)-Vesamicol reversibly and non-competitively inhibits the transport of acetylcholine into circulating synaptic vesicles and blocks the activity of vesicular acetylcholine transporters in medial amygdala neurons. (-)-Vesamicol is applicable to research related to central precocious puberty. | |||||||||||||||||||||
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References
- [1]. Searl T, et al. Acetylcholine recycling and release at rat motor nerve terminals studied using (-)-vesamicol and troxpyrrolium. The Journal of physiology. 1991 Dec;444:99-116. [Content Brief]
- [2]. Shen Y, et al. Early Exposure of an Infantile Rat to Sex-Related Content Induces Precocious Puberty by Activation of Cholinergic Neurons in the Amygdala and KNDy Neurons in the Arcuate Nucleus. ACS omega. 2025 Jul 22;10(28):30327-30334. [Content Brief]
