1154-78-5
Chemical Structure
Luteolinidin chloride
- CAS No.: 1154-78-5
- Formula:C15H11ClO5
- Molecular Weight:306.70
IUPAC Name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromenylium chloride
InChIKey: MMAGHFOHXGFQRZ-UHFFFAOYSA-N
SMILES: OC1=CC2=[O+]C(C3=CC=C(O)C(O)=C3)=CC=C2C(O)=C1.[Cl-]
Biological Activity: Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (Ki=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC50=3.7 μM) and blocks the production of melanin[1][2][3][4][5].
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Luteolinidin chloride | 99.91% | Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (Ki=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC50=3.7 μM) and blocks the production of melanin. | ||||||||||||||||||||
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References
- [1]. Maria JoãoMelo, et al. Photochemistry of luteolinidin: “Write-lock-read-unlock-erase” with a natural compound. Journal of Photochemistry and Photobiology A: Chemistry
- [2]. Boslett J, et al. Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H). J Pharmacol Exp Ther. 2017 Apr;361(1):99-108. [Content Brief]
- [3]. Bianco-Gomes AC, et al. Dry heat and pressure favor bioactive compounds preservation and peptides formation in sorghum [Sorghum bicolor (L.) Moench][J]. Curr Res Food Sci. 2022 Jan 4;5:117-124. [Content Brief]
- [4]. Boslett J J. CD38 in the Heart: Effects of CD38 Activation on Post-Ischemic Injury[D]. The Ohio State University, 2017.
- [5]. Yang S Y, et al. The Luteolinidin and Petunidin 3-O-Glucoside: A Competitive Inhibitor of Tyrosinase[J]. Molecules, 2022, 27(17): 5703. [Content Brief]
