115618-99-0
115618-99-0
Chemical Structure
Quinoprazine
- CAS No.: 115618-99-0
- Formula:C25H26N4
- Molecular Weight:382.50
IUPAC Name: N-(4-(4-ethylpiperazin-1-yl)phenyl)benzo[g]quinolin-4-amine
InChIKey: FGVVQTVRBTWGJA-UHFFFAOYSA-N
SMILES: CCN(CC1)CCN1C(C=C2)=CC=C2NC3=C4C=C5C=CC=CC5=CC4=NC=C3
Biological Activity: Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC50 value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrPSc levels[1]-[5].
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Quinoprazine | Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC50 value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrPSc levels-. | |||||||||||||||||||||
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References
- [1]. Mikhaĭlitsyn FS, et al. The search for new antiparasitic agents. 10. The synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine). Med P [Content Brief]
- [5]. Mikhaĭlitsyn FS, et al. The search for new antiparasitic agents. 8. The synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines]. Med Parazitol (Mosk). 1991 Sep-Oct;( [Content Brief]
