115787-68-3
115787-68-3
Chemical Structure
CI 972 anhydrous
- CAS No.: 115787-68-3
- Formula:C11H12ClN5OS
- Molecular Weight:297.76
IUPAC Name: 2,6-diamino-7-(thiophen-3-ylmethyl)-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride
InChIKey: SLNICZJKQXPOJA-UHFFFAOYSA-N
SMILES: O=C1C(NC(N)=C2CC3=CSC=C3)=C2NC(N)=N1.[H]Cl
Biological Activity: CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2].
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CI 972 anhydrous | CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent. | |||||||||||||||||||||
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References
- [1]. Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4. [Content Brief]
- [2]. Gilbertsen RB,et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8. [Content Brief]
