116700-36-8
116700-36-8
Chemical Structure
H-9 Dihydrochloride
- CAS No.: 116700-36-8
- Formula:C11H15Cl2N3O2S
- Molecular Weight:324.23
IUPAC Name: N-(2-aminoethyl)isoquinoline-5-sulfonamide dihydrochloride
InChIKey: HBLCYSFLYMHCBM-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC2=C1C=CN=C2)(NCCN)=O.[H]Cl.[H]Cl
Biological Activity: H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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H-9 Dihydrochloride | 98.98% | H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines. | ||||||||||||||||||||
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References
- [1]. Ito M, et al. A potent inhibitor of protein kinase C inhibits natural killer activity. Int J Immunopharmacol. 1988;10(3):211-6. [Content Brief]
- [2]. Vázquez-López A, et al. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochem Res. 2005 May;30(5):613-8. [Content Brief]
- [3]. Wollina U, et al. Inhibition of signal transduction in EGF-dependent epithelial cell lines. Int J Mol Med. 2003 Oct;12(4):673-7. [Content Brief]
