117056-67-4
Chemical Structure
12-NBD Stearate
- CAS No.: 117056-67-4
- Formula:C25H40N4O5
- Molecular Weight:476.61
IUPAC Name: 12-(methyl(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)octadecanoic acid
InChIKey: SAAVELCIPHKGJE-UHFFFAOYSA-N
SMILES: O=C(CCCCCCCCCCC(CCCCCC)N(C)C1=CC=C([N+]([O-])=O)C2=NON=C21)O
Biological Activity: 12-NBD Stearate is a fluorescent fatty acid analogue. 12-NBD Stearate binds to fatty acid binding protein (FABP) and sterol carrier protein-2 (SCP-2). Overexpressing sterol carrier protein-2 (SCP-2) 15-kDa isoform enhances 12-NBD Stearate transport. 12-NBD Stearate is a tool for microscopic long chain fatty acids (LCFA) uptake and internalization studies[1][2][3].
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12-NBD Stearate | 12-NBD Stearate is a fluorescent fatty acid analogue. 12-NBD Stearate binds to fatty acid binding protein (FABP) and sterol carrier protein-2 (SCP-2). Overexpressing sterol carrier protein-2 (SCP-2) 15-kDa isoform enhances 12-NBD Stearate transport. 12-NBD Stearate is a tool for microscopic long chain fatty acids (LCFA) uptake and internalization studies. | |||||||||||||||||||||
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References
- [1]. Murphy EJ. Sterol carrier protein-2 expression increases NBD-stearate uptake and cytoplasmic diffusion in L cells. Am J Physiol. 1998 Aug;275(2):G237-43. [Content Brief]
- [2]. Bass NM. Fatty acid-binding protein expression in the liver: its regulation and relationship to the zonation of fatty acid metabolism. Mol Cell Biochem. 1990 Oct 15-Nov 8;98(1-2):167-76. [Content Brief]
- [3]. Pohl J, et al. Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway. J Lipid Res. 2002 Sep;43(9):1390-9. [Content Brief]
