117442-28-1
Chemical Structure
Xenin-8
- CAS No.: 117442-28-1
- Formula:C51H79N15O9
- Molecular Weight:1046.27
IUPAC Name: L-histidyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl-L-leucine
InChIKey: QNDRYLNMRDPBTI-OBOKMFOZSA-N
SMILES: O=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H]2N(CCC2)C([C@@H](N)CC3=CNC=N3)=O)=O)=O)=O)N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC(C)C)=O)=O)CC4=CNC5=C4C=CC=C5
Biological Activity: Xenin-8 is the C-terminal octapeptide fragment of xenin, which belongs to the xenopsin family of peptides. Xenin-8 stimulates basal insulin secretion, dose-dependently enhances glucose (EC50 = 0.16 nM) and arginine-induced insulin release, and enhances arginine- and Carbamoylcholine chloride (HY-B1208)-induced glucagon secretion. Xenin-8 antagonizes the inhibition of glucagon release by elevated glucose. Xenin-8 can be used in research on type 2 diabetes and obesity-related glucose metabolic disorders[1].
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Xenin-8 | Xenin-8 is the C-terminal octapeptide fragment of xenin, which belongs to the xenopsin family of peptides. Xenin-8 stimulates basal insulin secretion, dose-dependently enhances glucose (EC50 = 0.16 nM) and arginine-induced insulin release, and enhances arginine- and Carbamoylcholine chloride (HY-B1208)-induced glucagon secretion. Xenin-8 antagonizes the inhibition of glucagon release by elevated glucose. Xenin-8 can be used in research on type 2 diabetes and obesity-related glucose metabolic disorders. | |||||||||||||||||||||
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