117675-21-5
117675-21-5
Chemical Structure
Zidovudine O-β-D-glucuronide
Synonym(s): 3'-Azido-3'-deoxythymidine β-D-glucuronide
- CAS No.: 117675-21-5
- Formula:C16H21N5O10
- Molecular Weight:443.37
InChIKey: NFXAJWJJNLWLOV-LHBOOPKSSA-N
SMILES: O=C1N(C=C(C(N1)=O)C)[C@@H]2O[C@@H]([C@H](C2)N=[N+]=[N-])CO[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O
Biological Activity: Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine[1][2][3].
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Zidovudine O-β-D-glucuronide | Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine. | |||||||||||||||||||||
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Zidovudine Glucuronide-13C6 | Zidovudine Glucuronide-13C6 (3'-Azido-3'-deoxythymidine β-D-glucuronide-13C6) is 13C labeled Zidovudine O-β-D-glucuronide. Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. | |||||||||||||||||||||
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References
- [1]. Walsky RL, et al. Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. Drug Metab Dispos. 2012;40(5):1051-1065. [Content Brief]
- [2]. Di Marco MP, et al. On-line deconjugation of glucuronides using an immobilized enzyme reactor based upon beta-glucuronidase. J Chromatogr B Biomed Sci Appl. 1998;715(2):379-386. [Content Brief]
- [3]. Tahara, T., et al. A novel 11C-labeled thymidine analog, [11C]AZT, for tumor imaging by positron emission tomography. EJNMMI Res 5, 45 (2015).
