1177356-70-5
1177356-70-5
Chemical Structure
(+)-Blebbistatin
- CAS No.: 1177356-70-5
- Formula:C18H16N2O2
- Molecular Weight:292.33
IUPAC Name: (R)-3a-hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
InChIKey: LZAXPYOBKSJSEX-SFHVURJKSA-N
SMILES: O[C@]12C(N(C3=CC=CC=C3)CC2)=NC4=CC=C(C)C=C4C1=O
Biological Activity: (+)-Blebbistatin is the inactive enantiomer of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective inhibitor of non-muscle myosin II ATPase activity[1][2][3][4][5].
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(+)-Blebbistatin | 98.17% | (+)-Blebbistatin is the inactive enantiomer of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective inhibitor of non-muscle myosin II ATPase activity. | ||||||||||||||||||||
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(+)-Blebbistatin (Standard) | ≥98% | (+)-Blebbistatin (Standard) is the analytical standard of (+)-Blebbistatin (HY-107657). This product is intended for research and analytical applications. (+)-Blebbistatin is the inactive enantiomer of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective inhibitor of non-muscle myosin II ATPase activity. | ||||||||||||||||||||
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References
- [1]. Allingham JS, et al. The structural basis of blebbistatin inhibition and specificity for myosin II. Nature structural & molecular biology. 2005 Apr;12(4):378-9.
- [2]. Limouze J, et al. Specificity of blebbistatin, an inhibitor of myosin II. Journal of muscle research and cell motility. 2004;25(4-5):337-41.
- [3]. Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellular calcium wave propagation in corneal endothelial cells. Investigative ophthalmology & visual science. 2008 Nov;49(11):4816-27. [Content Brief]
- [4]. Kovács M, et al. Mechanism of blebbistatin inhibition of myosin II. The Journal of biological chemistry. 2004 Aug 20;279(34):35557-63.
- [5]. Straight AF, et al. Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science (New York, N.Y.). 2003 Mar 14;299(5613):1743-7. [Content Brief]
