117761-01-0
117761-01-0
Chemical Structure
Z-Phe-Arg-pNA
- CAS No.: 117761-01-0
- Formula:C29H33N7O6
- Molecular Weight:575.62
InChIKey: SNRRZRWIWHSYLU-DQEYMECFSA-N
SMILES: O=[N+]([O-])C(C=C1)=CC=C1NC([C@H](CCCNC(N)=N)NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)=O
Biological Activity: Z-Phe-Arg-pNA is a chromogenic peptide substrate and a Cathepsin L substrate. Z-Phe-Arg-pNA is cleaved by recombinant CatL3. Z-Phe-Arg-pNA is used in the research of inflammatory bowel disease[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Z-Phe-Arg-pNA | 99.87% | Z-Phe-Arg-pNA is a chromogenic peptide substrate and a Cathepsin L substrate. Z-Phe-Arg-pNA is cleaved by recombinant CatL3. Z-Phe-Arg-pNA is used in the research of inflammatory bowel disease. | ||||||||||||||||||||
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References
- [1]. Šmid I, et al. Clitocypin, a fungal cysteine protease inhibitor, exerts its insecticidal effect on Colorado potato beetle larvae by inhibiting their digestive cysteine proteases. Pesticide biochemistry and physiology. 2015 Jul;122:59-66.
- [2]. Shoji A, et al. Inhibitory assay for degradation of collagen IV by cathepsin B with a surface plasmon resonance sensor. Journal of pharmaceutical and biomedical analysis. 2017 Oct 25;145:79-83.
- [3]. Hale LP, et al. Proteinase activity and stability of natural bromelain preparations. International immunopharmacology. 2005 Apr;5(4):783-93.
- [4]. Schmitz J, et al. 3-Cyano-3-aza-β-amino Acid Derivatives as Inhibitors of Human Cysteine Cathepsins. ACS medicinal chemistry letters. 2014 Oct 09;5(10):1076-81.
- [5]. Flury P, et al. Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity. ACS pharmacology & translational science. 2024 Feb 09;7(2):493-514.
- [6]. Malekar A. Recombinant Expression and Activity Determination of the Female Aedes aegypti Cathepsin L3 Protease (Master's thesis.
- [7]. Fricke B, et al. Characterization and purification of an outer membrane metalloproteinase from Pseudomonas aeruginosa with fibrinogenolytic activity. Biochimica et biophysica acta. 1999 Aug 30;1454(3):236-50.
