117829-60-4
Chemical Structure
JMV 170
- CAS No.: 117829-60-4
- Formula:C51H68N8O14S
- Molecular Weight:1049.21
IUPAC Name: (6S,9S,15S,18S,21S)-15-((1H-indol-3-yl)methyl)-9,18-dibutyl-2,2-dimethyl-4,7,10,13,16,19-hexaoxo-21-(phenethylcarbamoyl)-6-(4-(sulfooxy)benzyl)-3-oxa-5,8,11,14,17,20-hexaazatricosan-23-oic acid
InChIKey: DSQQKIGZFLQMRG-FDXDWZSASA-N
SMILES: C([C@@H](C(N[C@H](C(N[C@H](C(NCCC1=CC=CC=C1)=O)CC(O)=O)=O)CCCC)=O)NC(CNC([C@@H](NC([C@H](CC2=CC=C(OS(=O)(=O)O)C=C2)NC(OC(C)(C)C)=O)=O)CCCC)=O)=O)C=3C=4C(NC3)=CC=CC4
Biological Activity: JMV 170, a CCK derivative, is a selective CCK-B agonist. JMV 170 binds to the CCK-B receptor with a 10-fold higher affinity than to the CCK-A receptor. JMV 170 shows contractile effects on pig smooth muscle cells with an EC50 of 9 pmol/L[1][2].
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JMV 170 | JMV 170, a CCK derivative, is a selective CCK-B agonist. JMV 170 binds to the CCK-B receptor with a 10-fold higher affinity than to the CCK-A receptor. JMV 170 shows contractile effects on pig smooth muscle cells with an EC50 of 9 pmol/L. | |||||||||||||||||||||
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References
- [1]. Gue M, et al. Neuropeptide Y and sigma ligand (JO 1784) suppress stress-induced colonic motor disturbances in rats through sigma and cholecystokinin receptors. J Pharmacol Exp Ther. 1992 Jun;261(3):850-5. [Content Brief]
- [2]. Botella A, et al. Cholecystokinin and gastrin induce cell contraction in pig ileum by interacting with different receptor subtypes. Gastroenterology. 1992 Mar;102(3):779-86. [Content Brief]
