117978-26-4
Chemical Structure
A-62198
- CAS No.: 117978-26-4
- Formula:C30H44N8O5
- Molecular Weight:596.72
IUPAC Name: (S)-N-((2S,3R,4S)-5-azido-1-cyclohexyl-3,4-dihydroxypentan-2-yl)-3-(1H-imidazol-4-yl)-2-((S)-2-isobutyramido-3-phenylpropanamido)propanamide
InChIKey: KYZQHPHXYFTWRL-JSLVBRCRSA-N
SMILES: O[C@@H]([C@H](CN=[N+]=[N-])O)[C@@H](NC([C@H](CC1=CNC=N1)NC([C@H](CC2=CC=CC=C2)NC(C(C)C)=O)=O)=O)CC3CCCCC3
Biological Activity: A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses[1].
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A-62198 | A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses. | |||||||||||||||||||||
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