1180532-17-5
Chemical Structure
ITZ-1
- CAS No.: 1180532-17-5
- Formula:C20H20F5N3O3S3
- Molecular Weight:541.58
IUPAC Name: (Z)-N-(5,6-dimethyl-3-oxo-8-((4,4,5,5,5-pentafluoropentyl)thio)-2,3-dihydro-1H-imidazo[5,1-c][1,4]thiazin-1-ylidene)-4-methylbenzenesulfonamide
InChIKey: SCESDQSNIUARQD-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C)C=C1)(/N=C(C2=C(SCCCC(F)(F)C(F)(F)F)SC(C)=C(C)N23)\NC3=O)=O
Biological Activity: ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO)-induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases[1].
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ITZ-1 | ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO)-induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases. | |||||||||||||||||||||
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