1184173-73-6
1184173-73-6
Chemical Structure
MK-8353
Synonym(s): SCH900353
- CAS No.: 1184173-73-6
- Formula:C37H41N9O3S
- Molecular Weight:691.84
IUPAC Name: (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide
InChIKey: KPQQGHGDBBJGFA-QNGWXLTQSA-N
SMILES: O=C([C@@]1(SC)CN(CC(N2CC=C(C3=CC=C(C4=NN(C)C=N4)C=C3)CC2)=O)CC1)NC5=CC6=C(NN=C6C7=CC=C(OC(C)C)N=C7)C=C5
Biological Activity: MK-8353 (SCH900353) is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.
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MK-8353 | 98.13% | MK-8353 (SCH900353) is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity. | ||||||||||||||||||||
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MK-8353 (Standard) | ≥98% | MK-8353 (Standard) is the analytical standard of MK-8353 (HY-111407). This product is intended for research and analytical applications. MK-8353 (SCH900353) is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity. | ||||||||||||||||||||
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