1186532-61-5
Chemical Structure
BGC-20-1531
Synonym(s): PGN 1531
- CAS No.: 1186532-61-5
- Formula:C26H23N2NaO6S
- Molecular Weight:514.53
IUPAC Name: sodium (4-((4-(5-methoxypyridin-2-yl)phenoxy)methyl)-5-methylfuran-2-carbonyl)(o-tolylsulfonyl)amide
InChIKey: TVDHMDXPKGMXRT-UHFFFAOYSA-M
SMILES: O=C(C1=CC(COC2=CC=C(C3=NC=C(C=C3)OC)C=C2)=C(C)O1)N([Na])S(=O)(C4=C(C)C=CC=C4)=O
Biological Activity: BGC-20-1531 (PGN 1531), a benzenesulfonamide derivative, is a selective EP4 antagonist. BGC-20-1531 binds to PGE2 enhancing the ATPase activity, which are coupled to Gs proteins and thus activate adenylate cyclase generating cAMP and activating PKA. BGC-20-1531 is promising for research of liver disorders[1][2].
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BGC-20-1531 | BGC-20-1531 (PGN 1531), a benzenesulfonamide derivative, is a selective EP4 antagonist. BGC-20-1531 binds to PGE2 enhancing the ATPase activity, which are coupled to Gs proteins and thus activate adenylate cyclase generating cAMP and activating PKA. BGC-20-1531 is promising for research of liver disorders. | |||||||||||||||||||||
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References
- [1]. Ammazzalorso A, et al. N-acylsulfonamides: Synthetic routes and biological potential in medicinal chemistry. Chem Biol Drug Des. 2017 Dec;90(6):1094-1105. [Content Brief]
- [2]. Hodeify R, et al. PGE2 upregulates the Na+/K+ ATPase in HepG2 cells via EP4 receptors and intracellular calcium. PLoS One. 2021 Jan 14;16(1):e0245400. [Content Brief]
