1187396-28-6
Chemical Structure
TC-PTP-IN-1
- CAS No.: 1187396-28-6
- Formula:C46H62F2N5O9P
- Molecular Weight:897.98
IUPAC Name: ((4-((S)-3-(((S)-1-amino-6-(4-ethylbenzamido)-1-oxohexan-2-yl)amino)-2-((S)-2-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)-3-phenylpropanamido)-3-oxopropyl)phenyl)difluoromethyl)phosphonic acid
InChIKey: DZZMIHDOJVEPRL-OCPMFVFQSA-N
SMILES: O=P(O)(O)C(F)(F)C(C=C1)=CC=C1C[C@@H](C(N[C@H](C(N)=O)CCCCNC(C2=CC=C(C=C2)CC)=O)=O)NC([C@@H](NC(CO[C@@H]3[C@H](CC[C@@H](C3)C)C(C)C)=O)CC4=CC=CC=C4)=O
Biological Activity: TC-PTP-IN-1 (compound 8) is a potent TC-PTP inhibitor with an IC50 value of 9.2 nM, Ki values of 4.3, 34 nM for TC-PTP, PTP1B, respectively. TC-PTP-IN-1 increases the protein expression of pSre416[1]. TC-PTP-IN-1 (compound 3) is the TC-PTP Ligand of TP1L (HY-160151)[2].
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TC-PTP-IN-1 | TC-PTP-IN-1 (compound 8) is a potent TC-PTP inhibitor with an IC50 value of 9.2 nM, Ki values of 4.3, 34 nM for TC-PTP, PTP1B, respectively. TC-PTP-IN-1 increases the protein expression of pSre416. TC-PTP-IN-1 (compound 3) is the TC-PTP Ligand of TP1L (HY-160151). | |||||||||||||||||||||
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References
- [1]. Zhang S, et al. Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. J Am Chem Soc. 2009 Sep 16;131(36):13072-9. [Content Brief]
- [2]. Miao J, et al. Discovery of a selective TC-PTP degrader for cancer immunotherapy. Chem Sci. 2023 Oct 24;14(44):12606-12614. [Content Brief]
