1187460-81-6
1187460-81-6
Chemical Structure
(Rac)-PF-184
- CAS No.: 1187460-81-6
- Formula:C32H32ClFN6O4
- Molecular Weight:619.09
IUPAC Name: 8-(2-(3,4-bis(hydroxymethyl)-3,4-dimethylpyrrolidin-1-yl)-5-chloroisonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide
InChIKey: JUOWWGNRWRLBSV-UHFFFAOYSA-N
SMILES: O=C(C1=NN(C2=C1CCC3=C2C=C(NC(C4=CC(N5CC(CO)(C(CO)(C5)C)C)=NC=C4Cl)=O)C=C3)C6=CC=C(C=C6)F)N
Biological Activity: (Rac)-PF-184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 has anti-inflammatory effects[1].
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(Rac)-PF-184 | (Rac)-PF-184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 has anti-inflammatory effects. | |||||||||||||||||||||
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