1188407-45-5
1188407-45-5
Chemical Structure
BMS-764459
- CAS No.: 1188407-45-5
- Formula:C19H21F2N5O3
- Molecular Weight:405.40
IUPAC Name: (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-((6-(difluoromethoxy)-2,5-dimethylpyridin-3-yl)amino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile
InChIKey: PJMUNXORSUNUCV-OAHLLOKOSA-N
SMILES: N#CC(N=C1NC2=CC(C)=C(OC(F)F)N=C2C)=CN([C@@H](C3CC3)COC)C1=O
Biological Activity: BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer[1][2].
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BMS-764459 | BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer. | |||||||||||||||||||||
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References
- [1]. David K. Leahy, et al. Development of an Efficient Synthesis of Two CRF Antagonists for the Treatment of Neurological Disorders. Org. Process Res. Dev. 2010, 14, 5, 1221-1228.
- [2]. Simic D, et al. MicroRNA changes associated with atypical CYP1A1 inducer BMS-764459. Toxicology. 2013 Sep 15;311(3):169-77. [Content Brief]
