118850-71-8
Chemical Structure
Antiflammin-1
Synonym(s): Uteroglobin(39-47)
- CAS No.: 118850-71-8
- Formula:C45H82N12O14S2
- Molecular Weight:1079.33
IUPAC Name: (5S,8S,11S,14S,17S,20S,23S,26S,29S)-5-amino-8-(3-amino-3-oxopropyl)-14,17-bis(4-aminobutyl)-26-(carboxymethyl)-29-(hydroxymethyl)-23-isobutyl-20-isopropyl-11-(2-(methylthio)ethyl)-6,9,12,15,18,21,24,27-octaoxo-2-thia-7,10,13,16,19,22,25,28-octaazatriacontan-30-oic acid
InChIKey: XVZUZGWPOCVGGZ-NETRMLAPSA-N
SMILES: OC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCSC)NC([C@H](CCC(N)=O)NC([C@@H](N)CCSC)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Antiflammin-1 is an anti-inflammatory peptide 1 (MQMKKVLDS). Antiflammin-1 is a derivative of uteroglobin. Antiflammin-1 has anti-inflammatory and antifibrotic actions in bleomycin (HY-108345)-induced lung injury[1][2][3].
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Antiflammin-1 | Antiflammin-1 is an anti-inflammatory peptide 1 (MQMKKVLDS). Antiflammin-1 is a derivative of uteroglobin. Antiflammin-1 has anti-inflammatory and antifibrotic actions in bleomycin (HY-108345)-induced lung injury. | |||||||||||||||||||||
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References
- [1]. Liu W, et al. Antiflammin-1 attenuates bleomycin-induced pulmonary fibrosis in mice. Respir Res. 2013 Oct 8;14(1):101. [Content Brief]
- [2]. Camussi G, et al. Antiinflammatory peptides (antiflammins) inhibit synthesis of platelet-activating factor, neutrophil aggregation and chemotaxis, and intradermal inflammatory reactions. J Exp Med. 1990 Mar 1;171(3):913-27. [Content Brief]
- [3]. Martínez Leo EE, et al. Biopeptides with antioxidant and anti-inflammatory potential in the prevention and treatment of diabesity disease. Biomed Pharmacother. 2016 Oct;83:816-826. [Content Brief]
