1190948-58-3
1190948-58-3
Chemical Structure
Diptoindonesin G
- CAS No.: 1190948-58-3
- Formula:C21H12O6
- Molecular Weight:360.32
IUPAC Name: 4,7,9-trihydroxy-1-(4-hydroxyphenyl)-6H-anthra[1,9-bc]furan-6-one
InChIKey: BYHAUTWYDTUGRC-UHFFFAOYSA-N
SMILES: O=C1C2=C3C(OC(C4=CC=C(O)C=C4)=C3C5=C1C(O)=CC(O)=C5)=CC(O)=C2
Biological Activity: Diptoindonesin G is a 2-arylbenzofuran derivative and a modulator of estrogen receptor and HSP90 middle domain. Diptoindonesin G exhibits strong cytotoxicity against mouse leukemia P-388 cells with an IC50 of 13.2 μM. Diptoindonesin G has antitumor activity and can be used in the research of tumors such as breast cancer[1][2][3].
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Diptoindonesin G | Diptoindonesin G is a 2-arylbenzofuran derivative and a modulator of estrogen receptor and HSP90 middle domain. Diptoindonesin G exhibits strong cytotoxicity against mouse leukemia P-388 cells with an IC50 of 13.2 μM. Diptoindonesin G has antitumor activity and can be used in the research of tumors such as breast cancer. | |||||||||||||||||||||
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References
- [1]. Juliawaty LD, et al. A 2-arylbenzofuran derivative from Hopea mengarawan. Nat Prod Commun. 2009 Jul;4(7):947-50. [Content Brief]
- [2]. Liu JT, et al. Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors. Org Biomol Chem. 2016 Sep 26;14(38):8927-8930. [Content Brief]
- [3]. Donahue K, et al. Diptoindonesin G is a middle domain HSP90 modulator for cancer treatment. J Biol Chem. 2022 Dec;298(12):102700. [Content Brief]
