1192216-03-7
Chemical Structure
EphB4-IN-2
- CAS No.: 1192216-03-7
- Formula:C22H19N5O4
- Molecular Weight:417.42
IUPAC Name: 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
InChIKey: JTWMOWRMSZZHDR-UHFFFAOYSA-N
SMILES: CN(C1=C2N3C(N(C4=C(OC)C=CC=C4)C(C5=CC(O)=CC=C5C)=C3)=N1)C(NC2=O)=O
Biological Activity: EphB4-IN-2 is a tyrosine kinase inhibitor targeting the Eph family and Src family. EphB4-IN-2 binds to the ATP-binding site of the kinase domain of EphB4, and exhibits high affinity for tyrosine kinases with threonine as the gatekeeper residue, such as Abl, Lck and Src. EphB4-IN-2 can be used in research related to tumor-associated angiogenesis[1].
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EphB4-IN-2 | EphB4-IN-2 is a tyrosine kinase inhibitor targeting the Eph family and Src family. EphB4-IN-2 binds to the ATP-binding site of the kinase domain of EphB4, and exhibits high affinity for tyrosine kinases with threonine as the gatekeeper residue, such as Abl, Lck and Src. EphB4-IN-2 can be used in research related to tumor-associated angiogenesis. | |||||||||||||||||||||
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