119386-87-7
119386-87-7
Chemical Structure
JMV 179
- CAS No.: 119386-87-7
- Formula:C51H67N7O15S
- Molecular Weight:1050.18
InChIKey: IOXMTWKALARBDR-DNOUOQLUSA-N
SMILES: O=C(C[C@H](NC([C@@H](NC([C@H](NC(CNC([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC1=CC=C(C=C1)OS(=O)(O)=O)=O)CCCC)=O)=O)CC2=CNC3=C2C=CC=C3)=O)CCCC)=O)C(OCCC4=CC=CC=C4)=O)O
Biological Activity: JMV 179, a peptide closely related to CCK, is a cholecystokinin receptor (CKK) antagonist, with an IC50 of 30 nM[1][2].
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JMV 179 | JMV 179, a peptide closely related to CCK, is a cholecystokinin receptor (CKK) antagonist, with an IC50 of 30 nM. | |||||||||||||||||||||
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References
- [1]. K Kennedy, et al. Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin. J Biol Chem. 1997 Jan 31;272(5):2920-6. [Content Brief]
- [2]. S Silvente Poirot, et al. Study of the states and populations of the rat pancreatic cholecystokinin receptor using the full peptide antagonist JMV 179. Eur J Biochem. 1993 Mar 1;212(2):529-38. [Content Brief]
