1194396-71-8
Chemical Structure
Bimatoprost grenod
Synonym(s): NCX 470
- CAS No.: 1194396-71-8
- Formula:C31H46N2O8
- Molecular Weight:574.71
IUPAC Name: (S,E)-1-((1R,2R,3S,5R)-2-((Z)-7-(ethylamino)-7-oxohept-2-en-1-yl)-3,5-dihydroxycyclopentyl)-5-phenylpent-1-en-3-yl 6-(nitrooxy)hexanoate
InChIKey: NTQMJNDRYSYWNJ-BPXWCPHMSA-N
SMILES: O=C(O[C@@H](CCC1=CC=CC=C1)/C=C/[C@@H]2[C@@H](C/C=C\CCCC(NCC)=O)[C@@H](O)C[C@H]2O)CCCCCO[N+]([O-])=O
Biological Activity: Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bimatoprost grenod | 99.41% | Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma. | ||||||||||||||||||||
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References
- [1]. Impagnatiello F, et al. Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma. Br J Pharmacol. 2019 Apr;176(8):1079-1089. [Content Brief]
- [2]. Impagnatiello F, et al. Intraocular Pressure-Lowering Activity of NCX 470, a Novel Nitric Oxide-Donating Bimatoprost in Preclinical Models. Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6558-64. [Content Brief]
