119725-20-1
Chemical Structure
Fupenzic acid
- CAS No.: 119725-20-1
- Formula:C30H44O5
- Molecular Weight:484.67
IUPAC Name: (1R,2R,4aS,6aS,6bR,8aR,12aR,12bR,14bS)-1,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,12b,13,14b-hexadecahydropicene-4a(2H)-carboxylic acid
InChIKey: FMTPULGTIHBJRT-BBRBLNSOSA-N
SMILES: OC([C@]12[C@]([C@](O)([C@H](C)CC2)C)([H])C3=CC[C@@]([C@@]4([C@@](C(C)(C(C(O)=C4)=O)C)([H])CC5)C)([H])[C@]5(C)[C@]3(C)CC1)=O
Biological Activity: Fupenzic acid is a triterpenoid compound that can be found in the fruits of plants in the genus Rubus. Fupenzic acid inhibits LPS (HY-D1056)-induced NF-κB activation and reduces the expression of NO, NOS-2, COX-2, inflammatory cytokines, and chemokines. Fupenzic acid binds to RBMS1, downregulates RBMS1/cGAS/STING signaling, enhances PINK1/Parkin-mediated mitophagy, and alleviates oxidative stress and radiation-induced liver fibrosis. Fupenzic acid exhibits cytotoxic activity against various tumor cells and can inhibit melanin production. Fupenzic acid has inactivation, protective, and replication-inhibitory activities against TMV and CMV. Fupenzic acid can be used in research related to liver fibrosis, malignant glioma, colon cancer, gastric cancer, hepatocellular carcinoma, TMV, and CMV infection[1][2][3][4][5].
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Fupenzic acid | Fupenzic acid is a triterpenoid compound that can be found in the fruits of plants in the genus Rubus. Fupenzic acid inhibits LPS (HY-D1056)-induced NF-κB activation and reduces the expression of NO, NOS-2, COX-2, inflammatory cytokines, and chemokines. Fupenzic acid binds to RBMS1, downregulates RBMS1/cGAS/STING signaling, enhances PINK1/Parkin-mediated mitophagy, and alleviates oxidative stress and radiation-induced liver fibrosis. Fupenzic acid exhibits cytotoxic activity against various tumor cells and can inhibit melanin production. Fupenzic acid has inactivation, protective, and replication-inhibitory activities against TMV and CMV. Fupenzic acid can be used in research related to liver fibrosis, malignant glioma, colon cancer, gastric cancer, hepatocellular carcinoma, TMV, and CMV infection. | |||||||||||||||||||||
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References
- [1]. Boukerouis D, et al. Exploring the anti-inflammatory activity of fupenzic acid using network pharmacology and experimental validation. Scientific reports. 2025 Apr 24;15(1):14294.
- [2]. Guo X, et al. Fupenzic acid ameliorates radiation-induced liver fibrosis by regulating RBMS1 to inhibit the cGAS-STING pathway and restore mitochondrial function. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2026 Sep;159:158399. [Content Brief]
- [3]. Sun Z, et al. A novel nonreversible heat-induced low-molecular-weight gel based on naturally-occurring self-assembled fupenzic acid for tumor therapy. Colloids and surfaces. B, Biointerfaces. 2023 Aug;228:113392.
- [4]. Zhang J, et al. The triterpenoids and sesquiterpenoids from the plant of Agrimonia pilosa. Fitoterapia. 2022 Mar;157:105104. [Content Brief]
- [5]. Zhang X, et al. Antiphytoviral toxins of Actinidia chinensis root bark (ACRB) extract: laboratory and semi‐field trials. Pest management science. 2018 Jul;74(7):1630-6.
