1197334-04-5
1197334-04-5
Chemical Structure
SB 206553 hydrochloride
- CAS No.: 1197334-04-5
- Formula:C17H17ClN4O
- Molecular Weight:328.80
IUPAC Name: 5-methyl-N-(pyridin-3-yl)-3,5-dihydropyrrolo[2,3-f]indole-1(2H)-carboxamide hydrochloride
InChIKey: VGEMBOFBPSNOIO-UHFFFAOYSA-N
SMILES: O=C(N1C(C(CC1)=C2)=CC3=C2N(C)C=C3)NC4=CC=CN=C4.[H]Cl
Biological Activity: SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT2B / 5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92)[1]. SB 206553 possesses anxiolytic-like properties[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SB 206553 hydrochloride | 99.36% | SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT2B / 5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92). SB 206553 possesses anxiolytic-like properties. | ||||||||||||||||||||
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References
- [1]. Forbes IT, et al. 5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity. J Med Chem. 1995 Jul 7;38(14):2524-30. [Content Brief]
- [2]. Kennett GA, et al. In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties. Br J Pharmacol. 1996 Feb;117(3):427-434. [Content Brief]
