1197522-21-6
1197522-21-6
Chemical Structure
KIF18A-IN-4
- CAS No.: 1197522-21-6
- Formula:C22H27N3O3S
- Molecular Weight:413.53
IUPAC Name: N-(3-(cyclopentylsulfonyl)phenyl)-2-(piperidin-1-yl)nicotinamide
InChIKey: PGNDBHSSJBNDJL-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC(NC(C2=C(N3CCCCC3)N=CC=C2)=O)=C1)(C4CCCC4)=O
Biological Activity: KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity[1].
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KIF18A-IN-4 | KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity. | |||||||||||||||||||||
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