119784-94-0
119784-94-0
Chemical Structure
Tenidap sodium
Synonym(s): CP-66248 sodium
- CAS No.: 119784-94-0
- Formula:C14H8ClN2NaO3S
- Molecular Weight:342.73
IUPAC Name: sodium (Z)-(1-carbamoyl-5-chloro-2-oxoindolin-3-ylidene)(thiophen-2-yl)methanolate
InChIKey: VCSAHSDZAKGXAT-AFEZEDKISA-M
SMILES: O=C1/C(C2=CC(Cl)=CC=C2N1C(N)=O)=C(C3=CC=CS3)\O[Na]
Biological Activity: Tenidap is a non-steroidal anti-inflammatory active molecule and a selective inhibitor of COX-1, with IC50 values of 0.03 μM for COX-1 and 1.2 μM for COX-2. Tenidap exhibits anti-inflammatory and anti-rheumatic effects. Tenidap is a specific inhibitor of SLC26A3[1][2][3].
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Tenidap sodium | Tenidap is a non-steroidal anti-inflammatory active molecule and a selective inhibitor of COX-1, with IC50 values of 0.03 μM for COX-1 and 1.2 μM for COX-2. Tenidap exhibits anti-inflammatory and anti-rheumatic effects. Tenidap is a specific inhibitor of SLC26A3. | |||||||||||||||||||||
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References
- [1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [Content Brief]
- [2]. Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38(10):1447-56. [Content Brief]
- [3]. Chávez JC, et al. Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod. 2012 Jan 19;86(1):1-14. [Content Brief]
