1197958-53-4
1197958-53-4
Chemical Structure
ALK-IN-12
- CAS No.: 1197958-53-4
- Formula:C24H30ClN6O2P
- Molecular Weight:500.96
IUPAC Name: (2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
InChIKey: YHWJHUBPWLCING-UHFFFAOYSA-N
SMILES: CN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4P(C)(C)=O)=N3)C(OC)=C2)CC1
Biological Activity: ALK-IN-12 is a potent and orally active ALK inhibitor with an IC50 of 0.18 nM. ALK-IN-12 also inhibits IGF1R and InsR (IC50=20.3 and 90.6 nM). Antitumor activities[1].
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ALK-IN-12 | ALK-IN-12 is a potent and orally active ALK inhibitor with an IC50 of 0.18 nM. ALK-IN-12 also inhibits IGF1R and InsR (IC50=20.3 and 90.6 nM). Antitumor activities. | |||||||||||||||||||||
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