119813-87-5
Chemical Structure
rel-Delequamine
Synonym(s): rel-RS-15385-197
- CAS No.: 119813-87-5
- Formula:C18H26N2O3S
- Molecular Weight:350.48
IUPAC Name: (8aR,12aS,13aS)-3-methoxy-12-(methylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquinolino[2,1-g][1,6]naphthyridine
InChIKey: JKDBLHWERQWYKF-JLSDUUJJSA-N
SMILES: O=S(N1CCC[C@@]2(CN([C@]3(C[C@]12[H])[H])CCC4=C3C=CC(OC)=C4)[H])(C)=O
Biological Activity: rel-Delequamine (rel-RS-15385-197) is an orally active, brain-penetrant, potent and selective M2-adrenoceptor antagonist and α2-adrenoceptor antagonist. rel-Delequamine has a pKi of 9.45 for α2-adrenoceptors in the rat cortex. rel-Delequamine augments K+-evoked release of noradrenaline with an EC50 of 1 nM[1].
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rel-Delequamine | rel-Delequamine (rel-RS-15385-197) is an orally active, brain-penetrant, potent and selective M2-adrenoceptor antagonist and α2-adrenoceptor antagonist. rel-Delequamine has a pKi of 9.45 for α2-adrenoceptors in the rat cortex. rel-Delequamine augments K+-evoked release of noradrenaline with an EC50 of 1 nM. | |||||||||||||||||||||
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