120087-68-5
Chemical Structure
Echothiopate chloride
Synonym(s): Echothiophate chloride
- CAS No.: 120087-68-5
- Formula:C9H23ClNO3PS
- Molecular Weight:291.78
InChIKey: TWPQIWGWYLZCPK-UHFFFAOYSA-M
SMILES: O=P(OCC)(SCC[N+](C)(C)C)OCC.[Cl-]
Biological Activity: Echothiopate chloride (Echothiophate chloride) is an acetylcholinesterase (AChE) inhibitor. Echothiopate chloride irreversibly inhibits acetylcholinesterase, prevents the enzymatic hydrolysis of acetylcholine, and increases the local acetylcholine concentration in the ciliary muscle, thereby driving muscarinic receptor downregulation and regulatory hyposensitivity to Pilocarpine Hydrochloride. Echothiopate chloride can be used in the study of glaucoma[1][2].
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Echothiopate chloride | Echothiopate chloride (Echothiophate chloride) is an acetylcholinesterase (AChE) inhibitor. Echothiopate chloride irreversibly inhibits acetylcholinesterase, prevents the enzymatic hydrolysis of acetylcholine, and increases the local acetylcholine concentration in the ciliary muscle, thereby driving muscarinic receptor downregulation and regulatory hyposensitivity to Pilocarpine Hydrochloride. Echothiopate chloride can be used in the study of glaucoma. | |||||||||||||||||||||
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References
- [1]. Gabelt BT, et al. H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys. Investigative ophthalmology & visual science. 2004 Aug;45(8):2732-6.
- [2]. George C, et al. Regulation of acetylcholine synthesis in normal and neurotropic viral infected sympathetic ganglia. Brain Res. 1982 Jun 24;242(2):255-60.
