1203479-63-3
1203479-63-3
Chemical Structure
SRTCX1002
- CAS No.: 1203479-63-3
- Formula:C21H19N5O2S
- Molecular Weight:405.47
IUPAC Name: 2-(3-morpholinophenyl)-N-(thiazol-2-yl)-1H-benzo[d]imidazole-7-carboxamide
InChIKey: HVZCBEDNOBGKCN-UHFFFAOYSA-N
SMILES: O=C(NC1=NC=CS1)C2=C3NC(C4=CC=CC(N5CCOCC5)=C4)=NC3=CC=C2
Biological Activity: SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively[1].
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SRTCX1002 | SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively. | |||||||||||||||||||||
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